There’s no worse feeling than seeing a starting running back go down with an injury. Aside from the awful real-world ramifications, which can range anywhere from a day-to-day ankle sprain or a season-ending ACL tear, losing a player at the most important position in fantasy can put your roster in a real bind. However, in a sport as violent as football, injuries are an unfortunate reality. How fantasy managers prepare for the worst could be the difference between a championship and missing the playoffs entirely.

There are different ways to assess handcuffs. Some running backs have day-one value, even as backups. Others are currently irrelevant, but one injury could make them a valued commodity in any league. With offseason activity...

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